Psychiatry uncomfortably spans biological and psychosocial perspectives on mental illness, an idea central to Engel's biopsychosocial paradigm. This paradigm was extremely ambitious, proposing new foundations for clinical practice as well as a non-reductive metaphysics for mental illness. Perhaps given this scope, the approach has failed to engender a clearly identifiable research programme. And yet the view remains influential. We reassess the relevance of the biopsychosocial paradigm for psychiatry, distinguishing a number of ways in which it could be (re)conceived.

This paper resolves a paradox concerning colour constancy. On the one hand, our intuitive, pre-theoretical concept holds that colour constancy involves invariance in the perceived colours of surfaces under changes in illumination. On the other, there is a robust scientific consensus that colour constancy can persist in cerebral achromatopsia, a profound impairment in the ability to perceive colours. The first stage of the solution advocates pluralism about our colour constancy capacities. The second details the close relationship between colour constancy and (...) contrast. The third argues that achromatopsics retain a basic type of colour constancy associated with invariants in contrast processing. The fourth suggests that one person-level, conscious upshot of such processing is the visual awareness of chromatic contrasts ‘at’ the edges of surfaces, implicating the ‘colour for form’ perceptual function. This primitive type of constancy sheds new light on our most basic perceptual capacities, which mark the lower borders of representational mind. (shrink)

The orthodox monadic determination thesis holds that we represent colour relations by virtue of representing colours. Against this orthodoxy, I argue that it is possible to represent colour relations without representing any colours. I present a model of iconic perceptual content that allows for such primitive relational colour representation, and provide four empirical arguments in its support. I close by surveying alternative views of the relationship between monadic and relational colour representation.

Psychiatry widely assumes an internalist biomedical model of mental illness. I argue that many of psychiatry’s diagnostic categories involve an implicit commitment to constitutive externalism about mental illness. Some of these categories are socially externalist in nature.

Colour constancy is a foundational and yet puzzling phenomenon. Standard appearance invariantism is threatened by the psychophysical matching argument, which is taken to favour variantism. This argument, however, is inconclusive. The data at best support a pluralist view: colour constancy is sometimes variantist, sometimes invariantist. I add another potential explanation of these data, complex invariantism, which adopts an atypical six-dimensional model of colour appearance. Finally I prospect for a unifying conception of constancy among two neglected notions: discriminatory colour constancy and (...) relational colour constancy. The former arguably marks a common core capacity that is present across widely differing viewing contexts. (shrink)

This paper presents a new response to the colour similarity argument, an argument that many people take to pose the greatest threat to colour physicalism. The colour similarity argument assumes that if colour physicalism is true, then colour similarities should be scrutable under standard physical descriptions of surface reflectance properties such as their spectral reflectance curves. Given this assumption, our evident failure to find such similarities at the reducing level seemingly proves fatal to colour physicalism. I argue that we should (...) dispense with this assumption, and thus endorse the inscrutability of colour similarity. This strategy is inspired by parallels between the colour similarity argument and the explanatory gap between mind and body made vivid by Jackson’s (1986) knowledge argument, and in particular by type-B physicalist responses to that argument. This inscrutability response is further motivated by cases in chemistry and biochemistry in which analogous scrutability theses fail to hold. Along the way, I present a challenge to standard formulations of the colour similarity argument based on the extreme context sensitivity of the similarity relation. Most presentations of the argument fail to control for such contextual variation, which raises the distinct possibility that the argument equivocates on the similarity relation across its premises. Although ultimately inconclusive, this context challenge forces a significant reformulation of the colour similarity argument, and highlights the need for much greater care in handling claims about colour similarity. (shrink)

With contributions from psychiatry, psychology, neuroscience, and philosophy, this book provides the most comprehensive account to date of the interplay between biological, psychological, and social factors in mental health and their ethical dimensions.

Colour vision plays a foundational explanatory role in the philosophy of colour, and serves as perennial quarry in the wider philosophy of perception. I present two contributions to our understanding of this notion. The first is to develop a constitutive approach to characterizing colour vision. This approach seeks to comprehend the nature of colour vision qua psychological kind, as contrasted with traditional experiential approaches, which prioritize descriptions of our ordinary visual experience of colour. The second contribution is to argue that (...) colour vision does not constitutively involve the ability to see colours, in a natural and categorically committed sense. I argue that two subjects exactly alike in respect of their constitutive colour vision abilities could differ in respect of whether or not they have categorical perception of colour. The argument is supported by thought experiment and dissociations observed in cognitive neuropsychology. The argument also bears connections to recent neo-Whorfian accounts of colour categorization. _1._ Introduction _2._ Colour Vision, Experience, and Natures _3._ The Central Argument _3.1._ Colour constancy and discrimination _3.2._ Dissociating colour vision and categorical perception for colour _4._ Whorf and the View from Cognitive Neuropsychology _5._ Conclusion. (shrink)

I argue that it is possible to perceptually represent colour relations between two objects, without perceptually representing their colours. Such primitive relational colour representation goes against the orthodox view that we represent colour relations by virtue of representing colours. I first argue that under certain assumptions, PRCR is conceptually and even nomically possible. I then compare two possible models of PRCR: the linguaform model and chromatic edge model, the latter involving iconic rather than discursive representation. I argue that the chromatic (...) edge model gives a better account of putative cases of PRCR in cerebral achromatopsia, a rare disorder of colour consciousness. (shrink)

A growing body of literature critical of ethics review boards has drawn attention to the processes used to determine the ethical merit of research. Citing criticism on the bureaucratic nature of ethics review processes, this literature provides a useful provocation for (re)considering how the ethics review might be enacted. Much of this criticism focuses on how ethics review boards _deliberate,_ with particular attention given to the lack of transparency and opportunities for researcher recourse that characterise ethics review processes. Centered specifically (...) on the conduct of ethics review boards convened within university settings, this paper draws on these inherent criticisms to consider the ways that ethics review boards might enact more communicative and deliberative practices. Outlining a set of principles against which ethics review boards might establish strategies for engaging with researchers and research communities, this paper draws attention to how _Deliberative communication_, _Engagement with researchers_ and the _Distribution of responsibility_ for the ethics review might be enacted in the day-to-day practice of the university human ethics review board. This paper develops these themes via a conceptual lens derived from Habermas’ (The theory of communicative action. Volume 1: Reason and the rationalization of society, 1984 ) articulation of ‘communicative action’ and Fraser’s (Social Text, 25(26), 56–80, 1990 ) consideration of ‘strong publics’ to cast consideration of the role that human ethics review boards might play in supporting university research cultures. _Deliberative communication_, _Engagement with researchers_ and the _Distribution of responsibility_ provide useful conceptual prompts for considering how ethics review boards might undertake their work. (shrink)

The aim of the present study was to provide support for the validation of the Teammate Burnout Questionnaire. Athletes from a variety of team sports completed the TBQ and the Athlete Burnout Questionnaire. Confirmatory factor analysis revealed acceptable fit indexes for the three-dimensional models of the TBQ and the ABQ. Multi-trait multi-method analysis revealed that the TBQ and ABQ showed acceptable convergent and discriminant validity. The preliminary validation of the TBQ indicates the utility of the scale to reflect athletes’ perceptions (...) of their teammates’ burnout and offers researchers the opportunity to quantitatively assess an important aspect of the social environment in the development of athlete burnout. (shrink)

The problem of the will has long been viewed as central to Heidegger's later thought. In the first book to focus on this problem, Bret W. Davis clarifies key issues from the philosopher's later period--particularly his critique of the culmination of the history of metaphysics in the technological "will to will" and the possibility of Gelassenheit or "releasement" from this willful way of being in the world--but also shows that the question of will is at the very heart of (...) Heidegger's thinking, a pivotal issue in his path from Being and Time (1926) to "Time and Being" (1962). Moreover, the book demonstrates why popular critical interpretations of Heidegger's relation to the will are untenable, how his so-called "turn" is not a simple "turnaround" from voluntarism to passivism. Davis explains why the later Heidegger's key notions of "non-willing" and " Gelassenheit " do not imply a mere abandonment of human action; rather, they are signposts in a search for an other way of being, a "higher activity" beyond the horizon of the will. While elucidating this search, his work also provides a critical look at the ambiguities, tensions, and inconsistencies of Heidegger's project, and does so in a way that allows us to follow the inner logic of the philosopher's struggles. As meticulous as it is bold, this comprehensive reinterpretation will change the way we think about Heidegger's politics and about the thrust of his philosophy as a whole. (shrink)

The social impacts of computer technology are often glorified in public discourse, but there is growing concern about its actual effects on society. In this article, we ask: how does “consent” as an analytical framework make visible the social dynamics and power relations in the capture, extraction, and labor of data science knowledge production? We hypothesize that a form of boundary violation in data science workplaces—gender harassment—may correlate with the ways humans’ lived experiences are extracted to produce Big Data. The (...) concept of consent offers a useful way to draw comparisons between gender relations in data science and the means by which machines are trained to learn and reason. Inspired by how Big Tech leaders describe unsupervised machine learning, and the co-optation of “revolutionary” rhetoric they use to do so, we introduce a concept we call “techniques of invisibility.” Techniques of invisibility are the ways in which an extreme imbalance between exposure and opacity, demarcated along fault lines of power, are fabricated and maintained, closing down the possibility for bidirectional transparency in the production and applications of algorithms. Further, techniques of invisibility, which we group into two categories—epistemic injustice and the Brotherhood—include acts of subjection by powerful actors in data science designed to quell resistance to exploitative relations. These techniques may be useful in making further connections between epistemic violence, sexism, and surveillance, sussing out persistent boundary violations in data science to render the social in data science visible, and open to scrutiny and debate. (shrink)

Among industrialized nations the United States is relatively unique in relying on a mix of public and private financing and delivery of healthcare: federal and federal-state programs, such as Medicare and Medicaid; employment-based health insurance ; and state-subsidized insurance pools for high-risk individuals. In recent years, however, there have been efforts to apply the principles of private employment-based health insurance to the other forms of healthcare, and there is speculation that rising healthcare costs can only be addressed by further extending (...) capitated payment plans. This suggests that U.S. healthcare may increasingly be organized according to market principles. For some, this represents a historic departure from an emphasis on public responsibility for healthcare and a sacrifice of the value principles embodied in health relationships between patient and provider. But defenders of HMOs and a larger role for markets argue that managed care allows for a more rational allocation of scarce healthcare resources by minimizing inefficient low-benefit–high-cost care. More individuals receive essential care if inessential care is eliminated. HMOs are also said to encourage non-HMOs to provide lower priced healthcare. (shrink)

Benedict Spinoza (1634–1677) is feted as the philosopher par excellence of the popular democratic multitude by Antonio Negri and others. But Spinoza himself expresses a marked ambivalence about the multitude in brief asides, and as for his thoughts on what he calls “the rule of (the) multitude,” that is, democracy, these exist only as meager fragments in his unfinished Tractatus Politicus or Political Treatise. This essay addresses the problem of Spinoza’s multitude. First, I reconstruct a vision of power that is (...) found in the Ethics but that tends to be overlooked in the scholarly literature: power is not just sheer efficacy or imposition of will, but rather involves a capacity for being-affected; I call this the conception of power as sensitivity. The second part of my argument shows how, given Spinoza’s emphatic political naturalism, the conception of power as sensitivity can be extended to his political philosophy to shed light on what Spinoza calls potentia multitudinis, or “the power of the multitude”—a term found solely in the Political Treatise and nowhere else in his oeuvre. This juxtaposition reveals significant qualifications to the liberatory potential of the multitude currently claimed in the scholarly literature. (shrink)

‘Doing the will of God’, or seeking to do it, is a notion close to the centre of at any rate Christian, Jewish, and Moslem religion. So too is the notion of ‘accepting’ something as God's will: Fiat voluntas tua. In the former case, the notion of ‘doing the will of God’ is invoked in connection with what would be right to do in a practical situation; in the latter in connection with happenings and circumstances outside our control and as (...) something to be accepted rather than accomplished. I shall be concerned here with the notion of the will of God as something to be accomplished, asking what, if anything, to say that an action is in accordance with the will of God adds to saying that it is right. I shall also look at ways in which we think of relations between our wills and those of other people when we say that one person is doing the will of another person, and ask whether these help us at all in trying to see what might be meant by ‘doing the will of God’. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:328 HUME, MIRACLES AND LOTTERIES This paper addresses recent criticisms of Hume's skepticism with regard to miracles, by 1 2 Sorensen and Hambourger who argue that there are counterexamples, illustrated by lotteries, to Hume's account of how the truth of reports of improbable events (either first or second hand) must be evaluated. They believe these counterexamples are sufficient to prove that Hume's argument against the believability of miracles, defined (...) as violations of laws of nature caused by God, is unsound. Their arguments merit consideration not only in their own right but also on the basis of historical precedent, since they have in common an assumption that is found in Butler's criticism of Hume's predecessors in this debate. The bulk of my paper deals with Hambourger, who presents the most detailed version of the 'Butler' criticism. Sorensen's version can be answered in light of the evaluation of Hambourger 's argument. Hume's Argument Hume's argument is not against the possibility of miracles but against the possibility that it could ever be reasonable to believe a miracle 4 had occurred. His argument can be summed up as follows: in judging the credibility of a report of an improbable event, the probability of the event must be weighed against the probability that the report could be mistaken. The probability of an event is determined by the degree to which it conforms to known laws of nature. Laws of nature are formulated on the basis of uniform experience. Assuming that a miracle is a violation of laws of nature, any judgment that an event is miraculous presupposes a 329 judgment that there exists a uniform pattern of causation to which it is opposed, which pattern would constitute empirical proof against the miracle's occurrence. Testimony, on the other hand, is shown by experience not to be uniformly reliable. Consequently, no report of a miracle will have credibility since there will always be a uniform experience that is full proof against it, which therefore outweighs whatever merits testimony may have. In Hume's words, [N]o testimony is sufficient to establish a miracle, unless the testimony be of such a kind, that its falsehood would be more miraculous, than the fact, which it endeavors to establish.... When anyone tells me, that he saw a dead man restored to life, I immediately consider with myself, whether it be more probable, that this person should either deceive or be deceived, or that the fact, which he relates, should really have happened.... If the falsehood of his testimony would be more miraculous, than the event which he relates; then, and not till- then, can he pretend to command my belief or opinion (E 115-116). Hambourger 's Criticism Hambourger maintains that Hume's argument depends on a principle which he calls the "principle of relative likelihood." He restates this principle as follows: Suppose that someone or, perhaps, a group of people testify to the truth of a proposition P that, considered by itself, is improbable. Then to evaluate the testimony, one must weight (sic) the probability that P is true against the probability that the informants are lying or mistaken. If it is more likely that P is true than that the informants are lying or mistaken, then, on balance, the 330 testimony renders P more likely than not, and it may be reasonable for one to believe that P. However, if it is as likely, or even more likely, that the informants are lying or mistaken than it is that P is true, then, on balance, the testimony does not render P more likely true than false, and it would not be,reasonable for one to believe that P. As a counterexample to this principle, Hambourger asks us to suppose that a lottery is held in which there are one million entrants, each of whom has a one in a million chance of winning, and that a reliable newspaper, the New York Times, reports that the winner of the lottery is Smith. He further asks us to suppose that the Times errs only once out of every 10,000 times. Thus, the probability that the Times ' report is wrong is... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hume's Internalism1 Dorothy Coleman Hume is typically taken to be an internalist, that is, one who maintains that motivation is built into the acceptance or affirmation of a moral judgement.2However, Hume didnot provide any systematic defence of the internalist view, and consequently his views about moral motivation are problematic. Recently, for example, it has been argued that Hume is an externalist, one who maintains that the acceptance of (...) a mora] judgement does not itself motivate but requires independent desires to do so.3 This suggests thatclarification is needed to determine more precisely Hume's position on the issue ofmoral motivation. Since the distinction between internalism and externalism is a twentieth-century one,4 something should first be said about the wisdom of describing Hume in these terms. The contemporary debate between externalism and internalism concerns both the nature of moral motivation, whether moral judgements are themselves motivating, and the reason for this concern: internalists hold that motivation must be built into moraljudgements because it is "essential for an action's being or being shown to be obligatory."5 As Nagel puts it in ThePossibility ofAltruism, the problem with externalist accounts of motivation is that they cannot justify the requirement to perform one's obligations, "for they permit that someone who has acknowledged that he should do something and has seen why it is the case that he should do it, to ask ifhe has any reason for doing it."6 Seen in this way, the debate is about how to justify morality, how to account for our obligation to be moral at all, and how to answer the question, "Why ought I be moral?" Hume, on the other hand, was a thoroughgoing naturalist. He intended not tojustify morality but rather to provide its "natural history," a narration of the origin of moral concepts out of a set ofsocial and environmental conditions together with passions that constitute human nature. For example, concerning what he called the artificial virtues, such asjustice or the regardfor the public good, Hume argued that while the original motive to be just is self-interest, once individuals are educated and socialized into a community regulated by rules ofjustice, they come to "internalize" or moralize these norms so that their motive for being just is no longer self-interest but simply a regard for the public good, the sense ofjustice itself. Hume's concern with internalism, then, seems far removed from the problem of justifying morality that propels the current debate. Volume XVIII Number 2 331 DOROTHY COLEMAN Even though the internalist-externalist distinction applies only anachronistically to Hume, as long as those engaged in the contemporary debate insist on identifying historical figures as exemplars of one or the other of these viewpoints, and even disagree about who does and why,7 clarification of the extent to which this distinction can apply to Hume would be of assistance. Since the justification of morality is not a problem Hume addressed, for the purpose ofthis paper I will use the terms internalism and externalism to refer only to theories about moral motivation. To defend this interpretation ofHume, it will help first to clarify his terminology: whathe meantby moraljudgement, moral sense, and action from a sense ofduty. Hume claimed that moral judgements are based on feelings of pleasure or displeasure arising from impartial or disinterested reflection on the general influence ofmotives or traits of character. Those motives or passions that produce impartial feelings of approval are judged to be virtues; those that produce impartial feelings ofdisapproval arejudged to be vices.8 By moral sense or moral passions Hume meant feelings of approval and disapproval by which passions are judged to be virtuous or vicious.9 In defining duty or obligation, Hume stated that these are actions or qualities of mind whose neglect or non-performance causes disinterested displeasure or disapproval (T 517). To act from ásense ofduty or virtue would then be to be motivated by the sense whichjudges what our duties are, namely, bymoral passions, the feelings ofdisinterested approval ordisapproval ofmotives and the actions ofwhich they are signs. Thè Evidence for Hume's Internalism Hume's commitment to an internalist theory of ethical motivation is nowhere made explicit... (shrink)

Public discourse on race-specific medicine typically erects a wall between the scientific use of race as a biological category and the ideological battle over race as a social identity. Scientists often address the potential for these therapeutics to reinforce a damaging understanding of “race” with precautions for using them rather than questioning their very development. For example, Esteban Gonzalez Burchard, an associate professor of medicine and biopharmaceutical sciences at the University of California, San Francisco, states, “We do see racial differences (...) between populations and shouldn’t just close our eyes. Unfortunately, race is a politically charged topic, and there will be evildoers. But the fear should not outweigh the benefit of looking.” Although it is recognized that ideology influences thesocialmeaning of race, it is usually assumed that there is a separate, prior scientific understanding of race that is not contaminated by politics. (shrink)

The patient was a woman in her 30s who, until the rapid progression of an ultimately fatal neurologic disease, had been a very successful professional, enjoying athletics and an active social life. In the 6 months of swift deterioration, she had gone from being extremely vibrant and energetic to being totally unable to care for her personal needs. There had been no loss of intellectual capacity. Her sister later recounted to Dr. J., the emergency department physician, that she had found (...) the patient unconscious and unresponsive at home and had immediately called the patient's neurologist in a neighboring city. He directed her to call the paramedics. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:139 HUME'S "DIALECTIC" Hume's treatment of contradiction in his discussion of external existence has generally been understood to resemble the Pyrrhonian model of dialectic; consequently, Hume has been viewed as a sceptic and an irrationalist. According to that model of dialectic, the sceptic, by showing that equally strong arguments can be constructed both for and against a proposition, raises doubts about the ability of reason to determine the truth (...) or falsity of 2 beliefs. However, I will argue that Hume's treatment of contradiction differs significantly from Pyrrhonian dialectic. I will further argue that his treatment of contradiction is strongly analogous to the Kantian model of dialectic. According to Kant, dialectic is a method which not only shows that reason generates contradictions but which also provides a critique of 3 the logic generating those contradictions. The goal of Kant's dialectic is thus distinctly different from the goal of Pyrrhonian dialectic. For Kant, dialectic is a method for resolving scepticism. The parallels between Hume's treatment of contradiction and Kant's dialectic will suffice to show that Hume's "dialectic" is also a method for resolving, rather than generating, scepticism. Two features of Pyrrhonian dialectic have been deemed relevant for Hume's treatment of contradiction in his discussion of external existence. The Pyrrhonist argues that (1) if equally strong arguments can be given for and against a proposition, it is impossible to assess the truth or falsity of the proposition on the basis of any argument; and (2) if it 140 is impossible to assess rationally the truth or falsity of propositions, we must content ourselves in practical life with following custom and convention in all matters of opinion. Hume describes the contradiction in our belief in external existence as an opposition between two equally natural and unavoidable modes of inference. Both modes of inference are operations of the imagination. Hume does not give a special name to the first of these modes of inference, but he describes it as an "irregular" inference based upon the resemblance A of two distinct mental operations (T 203-204). The second is reflective, or causal, inference based on observation of the constant conjunction of like objects. Causal reasoning is reflective insofar as it is regulated by rules and is, consequently, a check or monitor for judgments resulting from the irregular or unchecked operation of the imagination. These two principles of inference lead to two different judgments about the nature of our perceptions: The imagination tells us, that our resembling perceptions have a continu'd and uninterrupted existence, and are not annihilated by their absence. Reflection tells us, that even our resembling perceptions are interrupted in their existence, and different from each other. (T 215) Just as the Pyrrhonian sceptic maintains that the constructibility of equally strong arguments establishing contradictory propositions makes it impossible to decide which proposition is true, Hume similarly maintains that two opposing modes of inference have an equal influence on the mind and therefore are "unable mutually to destroy each other" (T 215). However, Hume's account of this contradiction would be Pyrrhonian only if he argued that these principles, in addition to being equal in psychological 141 force, also have the same epistemic status. Only their having the same epistemic status makes it impossible to decide rationally whether one of the two principles is a reliable guide for making sound empirical inferences. Popkin, a defender of the Pyrrhonian reading of Hume, maintains that this is just what Hume does argue. Reflection for Hume, he maintains, is no more -a rational principle than is unchecked imagination: There is no rational basis for believing that those objects that have constantly been conjoined in the past, will be so conjoined in the future. It is only custom, or "a certain instinct of our nature," that makes us believe that they will be so conjoined, and this instinct which may be hard to resist psychologically, may well be fallacious and deceitful. The basis for all factual and probable reasoning is thus irrational. 5 If reflection is as irrational a principle as unchecked imagination, then the opposition between reflection and unchecked imagination would be an opposition between equally irrational principles. Consequently, a... (shrink)

Originally published in 1981. This is a book for the final year undergraduate or first year graduate who intends to proceed with serious research in philosophical logic. It will be welcomed by both lecturers and students for its careful consideration of main themes ranging from Gricean accounts of meaning to two dimensional modal logic. The first part of the book is concerned with the nature of the semantic theorist's project, and particularly with the crucial concepts of meaning, truth, and semantic (...) structure. The second and third parts deal with various constructions that are found in natural languages: names, quantifiers, definite descriptions, and modal operators. Throughout, while assuming some familiarity with philosophical logic and elementary formal logic, the text provides a clear exposition. It brings together related ideas, and in some places refines and improves upon existing accounts. (shrink)

It is controversial how best to classify conditionals. According to some theorists, the forward‐looking indicatives (those with a ‘will’ in the main clause) belong with the subjunctives (those with a ‘would’ in the main clause), and not with the other indicatives. The easy transition from typical ‘wills’ to ‘woulds’ is indeed a datum to be explained. Still, straightforward statements about the past, present or future, to which a conditional clause is attached—the traditional class of indicative conditionals—do (in my view) (...) constitute a single semantic kind. The theories I discuss do not fare better or worse when restricted to a particular subspecies. (shrink)

The host actin nucleation machinery is subverted by many bacterial pathogens to facilitate their entry, motility, replication, and survival. The majority of research conducted in the past primarily focused on exploitation of a host actin nucleator, the Arp2/3 complex, by bacterial pathogens. Recently, new studies have begun to explore the role of formins, another family of host actin nucleators, in bacterial pathogenesis. This review provides an overview of recent advances in the study of the exploitation of the Arp2/3 complex and (...) formins by bacterial pathogens. Secreted bacterial effector proteins seem to manipulate the regulation of these actin nucleators or functionally mimic them to drive bacterial entry, motility and survival within host cells. An enhanced understanding of how formins are exploited will provide us with greater insight into how a fundamental eurkaryotic cellular process is utilized by bacteria and will also advance our knowledge of host‐pathogen interactions. (shrink)

Discussion on the Platonic Socrates in relation to the historic Socrates has to some extent subsided in recent years. The older tradition looks like maintaining itself. But the question remains a provocative one, and further light on it would be welcome. It is some years, indeed, since Professor Field showed reason to doubt whether any further light will now be found, and advised reliance on the main line of tradition, through Aristotle, in the belief that we cannot in any case (...) reach behind it. (shrink)

The concept of the individual and his/her motivations is a bedrock of philosophy. All strands of thought at heart contain to a particular theory of the individual. Economics, though, is guilty of taking this hugely important concept without questioning how we theorize it. This superb book remedies this oversight. The new approach put forward by Davies is to pay more attention to what moral philosophy may offer us in the study of personal identity, self consciousness and will. This crosses the (...) traditional boundaries of economics and will shed new light on the distinction between positive and normative analysis in economics. With both heterodox and orthodox economics receiving a thorough analysis from Davies, this book is at once inclusive and revealing. (shrink)

There are certain ideals that can never be realised yet play an important role in our thinking, our morality, and our politics: they include the final comprehensive Truth, the General Will, the absolute Good, and certain religious ideals. Our attempts to get closer to them profoundly influence what we do, and our concern for them informs our criticism of what we reject. In politics, in particular, too many idealists are under the illusion that these ideals can be realised and if (...) disillusioned about this they too easily turn to cynicism - which is equally mistaken. This book looks at the role of such ideals in our intellectual and moral lives and in our politics by taking Kant's concept of the Regulative Ideal, and in so doing develops the concept itself further. Other thinkers whose ideas are considered in relation to this range from Plato to Iris Murdoch. (shrink)

According to Peter Galison , science has a highly fractionated structure with multiple sub-sub-disciplines, each with its own agenda. Cooperative trading between groups is necessary for most scientific work to move forward, and it is this trading that preserves the stability of science. We argue that it is not trading per se, but trading in a gift economy that guarantees stability. We support our claims with an examination of contemporary work on magnetic resonance imaging instrumentation. Specifically, we consider: How a (...) feature improvement, intended to reduce scan time, led to substantial medical mis-diagnosis; How a technical error, when corrected, created a consumer crisis in which radiologists preferred technically flawed instruments; How new magnetic resonance theory radically altered the physical interpretation of MRI images; How the MRI instrument at first was financially supported by, and--ironically--ultimately invalidated, the accepted understanding of the nature, source and management of chronic back pain. Ultimately there are three reasons stability requires gifting. First, without a general sense of shared purpose traders will not be committed to mutual engagement; profit does not provide an adequate shared purpose for the MRI community. Second, stability requires trust, and profits are not an adequate foundation for trust. Finally, knowledge is a gift that will not keep on giving if treated simply as a source of profit. (shrink)

When people go shopping for gametes, their first and most important criterion is the donor's race. In so choosing, they are making wrong and invidious assumptions about what race is. They are also assuming that their child will develop her sense of self within those parameters. The effect is harmful both for children and for society at large. People should be able to recognize racial categories as they construct their own identities, but those categories should not limit their self‐identification from (...) the very outset. (shrink)

Philosophy must diversify or die.There are forms of difference undreamt of in academic philosophy's current efforts at diversification.Is Philosophy Western? Was philosophy born and raised exclusively in the Western tradition, or can it be found in at least some non-Western traditions? Is the phrase "Western philosophy" a specific restriction of a more universal field, or is it, as Heidegger and others have claimed, a tautology since philosophy defines the essential core of the Western tradition and it alone?1 Is it true, (...) as Husserl thought, that "Europe is philosophy: the idea of Europe is the idea of philosophy—an idea of a universal rational science congruent with philosophy"?2 Or do such claims of what I will... (shrink)

At the beginning of Sein und Zeit, Martin Heidegger raises the question “What is the meaning of Being?”. In a celebrated review of Heidegger, Gilbert Ryle observes that, though some would quarrel with the assumption “that there is a problem about the Meaning of Being,” he, for the moment, will not. Why not? Because, says Ryle, the “question of the relation between Being qua timeless ‘substance’ and existing qua existing in the world of time and space seems to me a (...) real one.”. (shrink)

But what is thus presented is something additional to a study in the history of ideas. The author courageously undertakes not simply to recount but to interpret the story and, indeed, to point out the lesson to be learned from it. This lesson is not that we have gone astray and that our business is to discover where we took the wrong turning and who is chiefly responsible for this misdirection. On the contrary, the slow and difficult development of a (...) value-free mode of scientific thought is accounted a positive gain. But though this is so, we have no grounds for complacency. Indeed our present situation is described as one of crisis and predicament. This is because scientific success in the independent treatment of fact has not been matched by a comparable success in the independent treatment of value. The latter is our most pressing intellectual task and we are warned that it will be exceedingly difficult, requiring, indeed, the development of nothing less than a whole new logic and methodology. (shrink)

It is, I think, one of the outstanding characteristics of our age that during a short spell of thirty or forty years fundamental advances have been made in a large number of different sciences. These developments have altered almost every aspect of material life—they have certainly had great influence upon modern education, and upon modern ideas of politics, as well as upon a host of less important things. But chief of all we notice the effect of this Golden Age of (...) Science in the birth of new ideas. The revolution in ideas has only just started. Where it will end no one can see. (shrink)

Standard methods in experimental philosophy have sought to measure folk intuitions using experiments, but certain limitations are inherent in experimental methods. Accordingly, we have designed the Free-Will Intuitions Scale to empirically measure folk intuitions relevant to free-will debates using a different method. This method reveals what folk intuitions are like prior to participants' being put in forced-choice experiments. Our results suggest that a central debate in the experimental philosophy of free will—the “natural” compatibilism debate—is mistaken in assuming that folk intuitions (...) are exclusively either compatibilist or incompatibilist. They also identify a number of important new issues in the empirical study of free-will intuitions. (shrink)

When A utters a declarative sentence in a context to B, typically A can mean a proposition by the sentence, the sentence in context literally expresses a proposition, there are propositions A and B can agree the sentence literally expressed, and B can acquire knowledge from this testimonial exchange. In recent work on linguistic communication, each of these four platitudes has been challenged, and on the same basis: viz. on the ground that exactly which proposition the sentence expressed in context (...) is not discernible given the information provided by the context. I argue that, even if this is true, there will be propositional parts of the proposition expressed by the sentence in context which can be identified and that, consequently, the partial understanding afforded by the existence of such identifiable parts undermines the soundness of the arguments against the platitudes. (shrink)

Interpretation is an institutional activity and that may be the most significant fact about it; we are, indeed, a profession, and as such we train students to think about literature in certain ways. Membership in the community is determined by how well one masters the rules of the game. These inescapable facts may be the source of our greatest problems—or their hidden solution. Stanley Fish champions the latter alternative, arguing, in his most recent book, that “the interpretive community” is the (...) ultimate principle of authority in criticism and is capable of resolving all the problems of interpretation.1 If we want to know what reading is, how texts achieve determinate meaning, what constitutes validity in interpretation, or how to resolve the “conflict of interpretations,” we must, Fish argues, focus on the community itself, for it is here alone that these matters are determined.Though he has had more than his share of professional attention, having developed this argument makes Fish’s work worthy of further consideration. He quite simply presents the best picture we are likely to get of the “mind” of the profession, and, in treating him at length here, I am primarily concerned with his representative status. His great achievement is to have articulated the assumptions and beliefs underlying the practices that are favored in our profession: the tacit theoretical position composed of ideas and commonplaces that are so deeply held and constantly in use that they “prestructure” both our dealings with literature and our debates over those dealings. While remaining for the most part “unconscious,” these ideas nevertheless function as self-evident and unassailable truths. If we are to move, as I think we must, toward experiencing a crisis in our discipline, we first have to know where we are. And for that, Fish is invaluable because he has set out to become the official spokesman and efender of the profession. Walter A. Davis, associate professor of English at the Ohio State University, is the author of The Act of Interpretation: A Critique of Literary Reason. The present essay is from a recently completed work on contemporary criticism. He is currently writing a book on modern American drama. (shrink)

Withholding or withdrawing life-saving ventilators can become necessary when resources are insufficient. In the USA, such rationing has unique social justice dimensions. Structural elements of dominant allocation frameworks simultaneously advantage white communities, and disadvantage Black communities—who already experience a disproportionate burden of COVID-19-related job losses, hospitalisations and mortality. Using the example of New Jersey’s Crisis Standard of Care policy, we describe how dominant rationing guidance compounds for many Black patients prior unfair structural disadvantage, chiefly due to the way creatinine and (...) life expectancy are typically considered.We outline six possible policy options towards a more just approach: improving diversity in decision processes, adjusting creatinine scores, replacing creatinine, dropping creatinine, finding alternative measures, adding equity weights and rejecting the dominant model altogether. We also contrast these options with making no changes, which is not a neutral default, but in separate need of justification, despite a prominent claim that it is simply based on ‘objective medical knowledge’. In the regrettable absence of fair federal guidance, hospital and state-level policymakers should reflect on which of these, or further options, seem feasible and justifiable.Irrespective of which approach is taken, all guidance should be supplemented with a monitoring and reporting requirement on possible disparate impacts. The hope that we will be able to continue to avoid rationing ventilators must not stand in the way of revising guidance in a way that better promotes health equity and racial justice, both to be prepared, and given the significant expressive value of ventilator guidance. (shrink)

Book synopsis: The Cambridge philosopher Frank Ramsey died tragically young, but had already established himself as one of the most brilliant minds of the twentieth century. Besides groundbreaking work in philosophy, particularly in logic, language, and metaphysics, he created modern decision theory and made substantial contributions to mathematics and economics. In these original essays, written to commemorate the centenary of Ramsey's birth, a distinguished international team of contributors offer fresh perspectives on his work and show how relevant it is to (...) present-day concerns. Each of the ten essays addresses fundamental and contentious issues, including success semantics, propositions, infinity, conditionals, conceptual analysis, decision theory, and intergenerational justice. They also shed light on the intellectual context in which Ramsey developed his thought, including his relationship with such leading thinkers as John Maynard Keynes, Bertrand Russell, and Ludwig Wittgenstein. The volume will be indispensable reading for anyone interested in the recent history of philosophy and economics, as well as for practitioners and students of logic, metaphysics, philosophy of mathematics, philosophy of science, philosophy of mind, decision theory, and welfare economics. (shrink)

I Take it that my part in this series is not to set forward some particular world outlook, or even to describe different kinds of world outlook. That will have been done already much more adequately by the lecturers who precede me. My part is to discuss what in general is meant by world outlooks, why it is so difficult to arrive at agreement on them, and what kind of considerations should be taken into account in deciding for one rather (...) than another. (shrink)

A good deal of moral criticism employed in everyday life associates, in a variety of ways and in varying degrees of complexity, selfish behaviour and attitudes with a deficiency in what Dr Leavis calls ‘ethical sensibility’. A primitive ethical sensibility is a species of ignorance; it is to be unperceptive, muddled, superficial, undiscriminating and slipshod in one's understanding and appreciation of the nature and quality of one's own and other people's experience. It might involve, for example, being afflicted with sentimentalism; (...) perceiving people through a distorting medium of stereotypes or impressionistically; being dominated by wishful thinking in the Freudian sense; holding beliefs on the basis of hearsay, authority, or because it suits one to hold them; being immersed in situations and relationships whose continued existence requires self-deception; having the sense of one's own worth be wholly dependent upon the opinions of others. A developed ethical sensibility, on the other hand, includes what Professor Peters and others believe to be among the defining characteristics of rationality—impartiality; a caring for clarity, evidence, relevance, consistency and sincerity; a willingness to question authorities, tradition and one's own motives; refusing to be tempted by the cosiness of easy certainties and the stock response. The content of such a sensibility will, of course, depend upon the context in which reason is employed, and attempts to describe the content must take the form of a detailed discussion of particular cases. (shrink)

I present five theses to characterize and argue for "Instrumental Realism," a realism wedded to what we do with instruments, and not what our theories say: The Independence Thesis: Questions about realism are independent of questions about meaning. The Intervening Thesis: Our ability to produce consistent effects with our instruments provides one guarantee that we are engaged with the real world. The Historical Thesis: If the descriptions of what we know and do are of something real, then it will be (...) possible to trace a history from earlier antiquated names and actions to current usages. The Instruments-Do-Not-Always-Work-Right Thesis: Since instruments do not always work right, a successful instrumental intervention cannot be a social construct. The Tinkering Thesis: Since instruments are created by tinkering, we should not take any claim that generalizes away from our instrumental practice realistically. (shrink)